BCR-ABL Quantitative Real-Time PCR Kit

Real-Time Quantification of BCR-ABL Fusion Transcript Levels for CML Treatment Monitoring

Accurate measurement of BCR-ABL transcript burden is essential in clinical leukemia management. The BCR-ABL Quantitative Real-Time PCR Kit delivers real-time, highly sensitive quantification of the Major BCR-ABL breakpoint (p210) from blood and bone marrow RNA — enabling clinicians to detect minimal residual disease (MRD), assess treatment response, and optimize therapy for CML patients. Designed for precision laboratory diagnostics and treatment monitoring, the kit integrates seamlessly with OnePCR® Ultra-Fast POC System and Rapi-Q® Rapid PCR System, supporting results in a matter of hours instead of days.

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Overview

The BCR-ABL Quantitative Real-Time PCR Kit is a multiplex RT-qPCR assay for quantitative detection and measurement of BCR-ABL1 transcript levels relative to the ABL1 internal control gene. The kit includes Quantification Standards (QS1-QS4) to generate standardized calibration curves, allowing accurate calculation of copy number and international-scale normalized ratios for disease monitoring.

Ideal For
  • MRD monitoring in CML patients under TKI therapy
  • Baseline molecular quantification at diagnosis
  • Longitudinal monitoring during follow-up
  • Oncology & hematology lab workflows and point-of-care MRD support
Targets Quantified
  • Primary Target:
    BCR-ABL1 Major breakpoint (p210 – e14a2 & e13a2)
  • Internal Control:
    ABL1 gene
  • Quantification Standards:
    QS1–QS4 for calibration & international-scale conversion

Applications

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  • Quantitative MRD monitoring in CML patients
  • Treatment-response evaluation during TKI therapy (Imatinib, Dasatinib, Nilotinib)
  • Predicting relapse & therapy failure
  • Molecular classification support for leukemia workup
  • Oncology lab MRD testing & faster follow-up results

Key Features

Quantitative Real-Time PCR — calculates exact copy numbers & log reduction
Includes QS1-QS4 – built-in calibration for international-scale (IS) conversion
Works with whole blood or bone marrow (RNA)
Compatible with both OnePCR® fully-automated extraction-to-PCR and Rapi-Q® manual tube workflow
Results include Ct values, copy number, and % ratio on IS scale
Lyophilized components for ease of transport & long-term stability

Workflow / How It Works

With OnePCR® Ultra-Fast POC System
OnePCR® workflow

Collect blood or bone marrow sample | Extract RNA & load into Cartridge-1 | Reconstitute lyophilized QS & RM tubes in Cartridge-2 | Insert cartridges automatic processing | Results displayed as Copy Number, Ct Values, Standard Curve, & %IS Ratio

With Rapi-Q® System
Rapi-Q workflow

Extract RNA using Rapi-X16 module | Add RNA + buffer to RM & QS tubes | Load tubes start BCR-ABL Quantitative program | Software outputs Ct values & copy-number calculation

Ordering Information

Commercial Name Cat No. Pack Size Compatible Instruments
BCR-ABL Quantitative Real-Time PCR Kit G2M802821R-24T 24 Tests OnePCR Ultra-Fast POC System
BCR-ABL Quantitative Real-Time PCR Kit G2M802821R-48T 48T Rapi-Q Portable PCR System

Why Choose BCR-ABL Quantitative?

Enables accurate CML MRD monitoring vs. qualitative confirmation
Supports precision-medicine-based treatment decisions
Ideal for oncology centers, hematology departments & molecular labs
Compatible with portable POC platforms for faster reporting

Resources to get started

Download useful documents and technical information for the BCR ABL-Quantitative RT-PCR Kit.

Product Brochure
IFU (Instructions for Use)
Report File

Product Enquiry Form

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Since its inception in 2016, Genes2me has been constantly striving towards setting a benchmark in the diagnostics space by introducing premium quality (Made in India) diagnostic kits which are CE-IVD, ISO-13485:2016, and ISO 9001:2015 certified, assuring our clients of unparalleled quality and compliance with international standards.

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