Microarray Analysis

High Resolution microarray panels which screens for submicroscopic chromosomal changes in DNA with whole genome coverage.

CMA looks for imbalances in the amount of chromosomal material in a DNA sample by comparing it with a reference database. This information helps determine type of disorder in the sample.

CytoPrime

Optimized molecular cytogenetics assay for prenatal and miscarriage samples

Price: ₹20000.00

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Probe Density - 315K

Detection Range - Upto 500 Kb for gains and losses

Recommended for following Cases-:

IVF
RPL
Pediatric (when confirming a syndrome)
USG finding
Confirming a positive NIPT finding

CytoSure

Whole Genome coverage without compromise on delivering excellence in specificity, sensitivity and resolution.

Price: ₹27000.00

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Probe Density - 750 K

Detection range - Upto 100 Kb for gains and losses

Recommended for following cases

Autism
Ideopathic pediatric disorders
USG finding
DD
ID
family history of disorders
USG finding

CytoPerfect

The unrivaled standard in cytogenetics with superior resolution for whole genome analysis for research studies!

Price: ₹47000.00

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Probe Density

2.67 Million

Detection range

Upto 25 Kb for gains and losses

Recommended for following cases

Autism
Ideopathic pediatric disorders
USG finding
DD
ID
family history of disorders
USG finding

What CMA delivers ?

Information about Submicroscopic Chromosomal Genetic Changes in DNA, which might not be picked up by routine techniques such as FISH and Karyotyping.

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Whole Genome information through ACMG and ACOG recommended First Line Genetic Tests for Postnatal and prenatal screening respectively.
Greater Diagnostic yield (20-25%) over traditional chromosomal analysis with Karyotyping / FISH (3-5%)
Fast TAT to report with whole genome information in 8-10 working days.

Specification

Test	SNP/CNV	Probe Density	Detection range	Recommended for following cases
CytoSure	vv	750K	Upto 100 Kb for gains and losses	Autism,Ideopathic pediatric disorders,USG finding,DD,ID,family history of disorders,USG finding
CytoPerfect	vv	2.67 Million	Upto 25 Kb for gains and losses	Autism,Ideopathic pediatric disorders,USG finding,DD,ID,family history of disorders,USG finding

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Test	SNP/CNV	Probe Density	Detection	Recommended for following cases
CytoPrime	√√	315K	Upto 500 Kb for gains and losses	IVF,RPL,Pediatric (when confirming a syndrome),USG finding,Confirming a positive NIPT finding
CytoSure	√√	750K	Upto 100 Kb for gains and losses	Autism,Ideopathic pediatric disorders,USG finding,DD,ID,family history of disorders,USG finding
CytoPerfect	√√	2.67 Million	Upto 25 Kb for gains and losses	Autism,Ideopathic pediatric disorders,USG finding,DD,ID,family history of disorders,USG finding

Comparison of CMA with other Tests

FEATURES	KARYOTYPE	FISH/QF-PCR	CMA
Coverage	Whole Genome	Probe Specific	Whole Genome
Resolution	>5 Mb	>100 Kb	>100 Kb
Live Cells	Required	Not Required	Not required
MCC pick up	No	No	Yes
Failure Rate	30-40% due to culture failure/ contamination	No	Very Rare
Balanced Translocation	Yes	Yes	No
Unbalanced Translocation	Yes	Yes	Yes
Gain/Loss	Yes	Yes	Yes
Micro-deletion/	Yes	Yes	Yes
Duplication	Yes	Yes	Yes
Mosaicism	Yes	Yes	Yes
Triploidy	Yes	Yes	Yes
Additional Information	Yes	Yes	Yes

What it screens?

Developmental delay (DD)
(Recommended as First Line Test by ACMG)	Autism
	Intellectual disability (ID)
Micro-deletion and Micro-duplication syndromes	Prader-Willi/Angelman syndrome
Wolf-Hirschhorn syndrome
Williams – Beuren syndrome
DiGeorge Syndrome
Smith-Magenis Syndrome/Potocki -- Lupski Syndrome
Ultrasound Abnormalities –Recommended as first line test by ACOG	Absent nasal bone
Increased NT
Ventriculomegaly
Polydactyly
Syndactyly
Repeated Pregnancy Loss (RPL)	Couples CMA analysis
POC analysis
Others	Uniparental Disomy (UPD) and Loss of heterozygosity (LOH)
Low level mosaicism
Trisomy/Triploidy