The PanCan is a comprehensive cancer diagnosis NGS panel capable of screening all variant types and immuno-oncology markers (MSI and TMB), which are crucial biomarkers for cancer immunotherapy. For CNV analysis, different cut-offs are applied according to the ratio of cancer cells. The panel is also designed to detect Epstein-Barr virus (EBV) and Human Papillomaviruses (HPV), allowing for the comprehensive analysis of cancer-associated genes.
This PanCan panel supports screening of a total of 524 genes using as little as 50 ng genomic DNA from FFPE or fresh frozen tissue and enables detection of mutations like SNV, INDELS, CNV, Chromosomal Rearrangement as well as important immuno-oncology markers (TMB and MSI).
Panel is also equipped to detect variants of EBV and HPV viruses that are known to be associated with onset and progression of carcinoma in humans. The panel encompasses whole CDS, custom regions of various oncogenes, Immune response genes as well as EBV and HPV virus genes generating a total of 2.5Mb sequencing data.