There are two genes, namely, BRCA1 & BRCA 2 which are found in every normal individual. But any genetic variation or mutations occurring in either of these two genes, can lead to the incidence of breast, ovarian, and to a lesser extent other cancers such as prostate cancer, pancreatic cancer & melanoma.
BRCA mutations can occur in any individual irrespective of their gender or ethnicity
BRCA mutations can occur in any individual irrespective of their gender or ethnicity. Ideally, breast cancer screening should be brought into a regular practice for any normal individual. But for people, having a family history or any affected member in the family, breast cancer screening is highly recommended. In India the incidence of breast cancer is significantly lower than western countries. Breast cancer in India ranges from as low as 5 per 100,000 women per year in rural areas to 30 per 100,000 women per year in urban areas. But the cases of breast cancers are increasing in an alarming rate. Incidence of breast cancer increases with age; albeit the main risk factor is genetic predisposition but other risk factors such as reproductive, lifestyle or environmental factors have been also reported.
Both male and female have mammary glands.
Both male and female have mammary glands. But the difference lies in the fact that, in men, mammary glands are in rudimentary state and are inactive. A lot of familial and sporadic cases of male breast cancers have been reported in the past. Men with mutations in the BRCA1/2 genes have been affected with prostate cancers. In fact, BRCA2 mutations may prove to be a greater cause of cancer in men than had previously been though.
Genes2me offer a thorough screening of BRCA1 and BRCA2 mutations
Genes2me offer a thorough screening of BRCA1 and BRCA2 mutations, which helps in identifying the clinically relevant or pathogenic mutations. Our panel of breast cancer screening covers most of the reported and commonly occurring mutations. Screening is performed on a high end and sophisticated platform of Next generation sequencing (NGS) technique. Regular screening aids early diagnosis, which provides a bigger room for complete cure of breast or ovarian cancer.
Mutations in the BRCA1 and BRCA2 genes are inherited in an autosomal dominant pattern
Mutations in the BRCA1 and BRCA2 genes are inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase a person's chance of developing cancer. Although breast cancer is more common in women than in men, the mutated gene can be inherited from either the mother or the father. But, not all breast cancers are inherited. These cancers are acquired during a person's lifetime, and they do not cluster in families.
In all cases, you should discuss the results and any appropriate follow-up with your referring clinician.
If you are positive for a BRCA mutation
If you are positive for a BRCA mutation, there are several options that you and your physician could consider to reduce the risk for developing cancer. Your options may include:
It is important to discuss these options with your doctor and/or your genetic counselor to understand which option is best for you.
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