brca-screening

BRCA Screening

There are two genes, namely, BRCA1 & BRCA 2 which are found in every normal individual. But any genetic variation or mutations occurring in either of these two genes, can lead to the incidence of breast, ovarian, and to a lesser extent other cancers such as prostate cancer, pancreatic cancer & melanoma.

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brca-screening
Who is at risk ?
Who is at risk ?

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  • Gender: Just being a woman is the major risk factor, but men get breast cancer too.
  • Age: Incidence increases with age.
  • Family: Women with first-degree female relative (sister, mother, daughter) diagnosed with breast cancer, have a higher risk of developing the cancer.
  • Genetics: About 5% -10% of breast cancers are thought to be hereditary.
  • Personal Health History: Women who have had breast cancer are more likely to get breast cancer a second time.
How is a BRCA mutation inherited?
How is a BRCA mutation inherited?

Mutations in the BRCA1 and BRCA2 genes are inherited in an autosomal dominant pattern

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Mutations in the BRCA1 and BRCA2 genes are inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase a person's chance of developing cancer. Although breast cancer is more common in women than in men, the mutated gene can be inherited from either the mother or the father. But, not all breast cancers are inherited. These cancers are acquired during a person's lifetime, and they do not cluster in families.

In all cases, you should discuss the results and any appropriate follow-up with your referring clinician.

Are males also affected ?
Are males also affected ?

Both male and female have mammary glands.

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 Both male and female have mammary glands. But the difference lies in the fact that, in men, mammary glands are in rudimentary state and are inactive. A lot of familial and sporadic cases of male breast cancers have been reported in the past. Men with mutations in the BRCA1/2 genes have been affected with prostate cancers. In fact, BRCA2 mutations may prove to be a greater cause of cancer in men than had previously been though.

What options do I have if I carry a BRCA mutation ?
What options do I have if I carry a BRCA mutation ?

If you are positive for a BRCA mutation

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If you are positive for a BRCA mutation, there are several options that you and your physician could consider to reduce the risk for developing cancer. Your options may include:

  • Increased or enhanced screening for cancer
  • Proactive (prophylactic) surgery
  • Drug therapy (chemoprevention)
  • Evaluation of your family members’ risk

It is important to discuss these options with your doctor and/or your genetic counselor to understand which option is best for you.

Why Genes2me in BRCA?
Why Genes2me in BRCA?

Genes2me offer a thorough screening of BRCA1 and BRCA2 mutations

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 Genes2me offer a thorough screening of BRCA1 and BRCA2 mutations, which helps in identifying the clinically relevant or pathogenic mutations. Our panel of breast cancer screening covers most of the reported and commonly occurring mutations. Screening is performed on a high end and sophisticated platform of Next generation sequencing (NGS) technique. Regular screening aids early diagnosis, which provides a bigger room for complete cure of breast or ovarian cancer.

What do I do if I carry a BRCA mutation?

brca-screening
How it Works
Order a Kit

Order and receive Saliva Collection Kit
 

Collect Your Sample

Collect the Saliva sample from your mouth

Lab Processing

Expert scientific team for highly accurate results

Get Your Reports

Your Genetic Insights are on Your Way

Genetic Counseling

Pre & post test counseling with a Genetic Expert

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